Colorado Buffaloes vs BYU Cougars — DeepSeek betting tip 28 September 2025.

This matchup presents a clear value opportunity on BYU despite the steep odds. The Cougars' moneyline at 1.41 implies a 71% win probability, which aligns well with their roster advantages and scheme fit against Colorado. BYU returns dual-threat QB Gerry Bohanon and a physical offensive line – critical weapons against a Buffaloes defense that allowed 34.8 points per game last season and remains vulnerable between the tackles. Colorado's offensive line struggles (3.3 sacks allowed per game in 2024) play directly into BYU's defensive strength: an aggressive front seven that generated 32 sacks last year.

While the altitude in Boulder provides some home-field edge, Colorado's reliance on unproven transfers in the secondary and inconsistent run defense creates exploitable mismatches. BYU's run-first identity travels effectively, and their disciplined defense should contain Colorado's explosive but inconsistent passing attack. Historical trends also favor the Cougars – Power Five road favorites with implied probabilities over 65% cover roughly 58% of the time against defensively challenged opponents like Colorado.

The +205 odds on Colorado are enticing for risk-takers, but the gap in trench play and quarterback experience makes BYU the fundamentally sound choice. Barring multiple turnovers or special teams breakdowns from BYU, their physicality and execution in critical downs should control this game from the second quarter onward.