Betting tips from AI for Arizona Cardinals vs Atlanta Falcons, 21 December 2025.

The market makes Atlanta the clear favorite at 1.65, while Arizona sits as the plus-money underdog at 2.36. SportsGambler still gives the Falcons a 61% edge and several handicappers expect a shootout, but the matchup contains exploitable angles for the visitors.

Arizona's injury-driven 65% pass rate against a Falcons secondary that has surrendered big through the air, plus Fox Sports' model projecting a 24-23 Cardinals edge and Atlanta's shaky 1-5 ATS mark as favorites, swings value to the Cards. I expect a close, high-scoring game where taking Arizona at plus-money is the profitable play.

The Atlanta Falcons, despite being the 1.65 favorites, have a dreadful 1-5 ATS record when favored, often losing outright. This sets up a prime opportunity for the Arizona Cardinals, priced at 2.36. Arizona has a history of covering as home underdogs (4-4 ATS) and even upset Atlanta 25-23 in their last meeting at State Farm Stadium. With the Cardinals' injury-forced aerial attack (65% pass snaps) poised to challenge Atlanta's weak pass defense, a high-scoring shootout is likely. Fox Sports’ model even predicts a narrow Cardinals win, making them the smart bet for an upset.

This Cardinals-Falcons matchup has all the ingredients for a high-scoring affair. Arizona enters on a six-game losing streak but their pass-heavy approach (65% of snaps) could exploit Atlanta's vulnerable secondary. The Falcons have been terrible as favorites this season, going 1-5 ATS and losing all five outright. That's a major red flag despite their 1.65 favorite status.

While computer models from Fox Sports suggest a Cardinals 24-23 win, the betting trends are particularly compelling. Arizona is 4-4 ATS as 3-point underdogs this season and has recent success against Atlanta, including a 25-23 win in their last meeting at State Farm Stadium.

The Falcons' defensive struggles against the pass align perfectly with Arizona's forced aerial attack due to running back injuries. Given Atlanta's 1-5 record as favorites and Arizona's home-field advantage, the Cardinals at 2.36 represent strong value in what should be a close, high-scoring contest.

The NFL clash in Glendale pits a slumping Arizona Cardinals squad against the Atlanta Falcons, with the home underdogs offering juicy value at 2.36. Arizona's mired in a brutal six-game skid, fresh off a 40-20 drubbing by Houston, but they've got that home-field magic—stunning Atlanta 25-23 in their last State Farm Stadium showdown. As 3-point underdogs, they're 4-4 ATS this season, and with running back injuries forcing a pass-heavy attack (65% of snaps, second-most in the NFL), this could exploit Atlanta's leaky secondary that's surrendered big through the air lately.

The Falcons limp in at 5-9, winners of two of their last four, but they're a dismal 1-5 ATS as favorites this year—dropping all five outright. Six of their last seven games have exploded over the total, hinting at a shootout here against shaky defenses on both sides. While experts like SportsGambler give Atlanta a 61% edge and Winners and Whiners see them edging 28-27, Fox Sports' model predicts a nail-biter with the Cards winning 24-23. That recent ATS trend for Atlanta screams regression, and Arizona's home underdog bite makes them the play for bettors chasing profit.

Betting $1 on the Cardinals at 2.36 could yield a smart payout in this thriller, where the underdog's resilience shines through.

The stage is set for a shootout in Glendale, with both defenses vulnerable and points likely to flow.
Betting experts see Atlanta favored, but their 1.65 odds hide a dismal 1-5 record as favorites this season, losing all five outright.
Meanwhile, Arizona's forced air attack—passing on 65% of snaps—could exploit Atlanta's leaky secondary, and Fox Sports' model predicts a 24-23 Cardinals win.
With home advantage and a recent 25-23 victory over the Falcons here, the Cardinals at 2.36 present compelling value in a nail-biter.

This matchup between the Arizona Cardinals and Atlanta Falcons shapes up as a potential shootout, with both teams showing glaring defensive vulnerabilities. The Falcons enter as favorites with odds of 1.65, but their struggles against the spread (ATS) this season are alarming—just 1-5 ATS as favorites, losing all five outright. Meanwhile, the Cardinals, despite being on a six-game losing streak, have shown resilience at home, particularly in close games like their last meeting with Atlanta, which they won 25-23.

Arizona’s reliance on their passing game due to injuries at running back could play right into Atlanta's hands, given the Falcons' tendency to give up big plays through the air. However, Atlanta’s own defense has been equally porous, allowing high-scoring affairs in six of their last seven games. With experts split between a narrow Cardinals win (Fox Sports) and a thrilling Falcons victory (Winners and Whiners), the edge may lie in Arizona’s ability to cover as underdogs. Their ATS record of 4-4 as 3-point underdogs suggests they can keep games competitive even when outmatched.

The total points prediction leans heavily toward the over, but for picking a winner, the value lies with Arizona at 2.36. The Cardinals’ familiarity with close wins against Atlanta and the Falcons’ inability to capitalize as favorites make Arizona the smarter bet here.