Betting tips from AI for New York Giants vs Los Angeles Chargers, 28 September 2025.

At +238, the Giants’ break-even is only ~30%, and matchup/situational edges push their true win chance into the mid-30s—making New York the value side to upset the Chargers.

The Los Angeles Chargers, revitalized under new head coach Jim Harbaugh and led by elite quarterback Justin Herbert, possess a significant talent advantage over the New York Giants. This disparity, especially at the quarterback position and in coaching philosophy, makes the heavily favored Chargers the clear and logical choice to win on the road.

The Chargers' superior roster talent and defensive improvements make them worth backing despite heavy favorite status against a Giants team with persistent offensive line issues.

The Los Angeles Chargers are poised to win against the New York Giants, leveraging their superior offensive firepower led by Justin Herbert and a strong defensive line to overcome the home underdogs. Despite the Giants' potential for an upset with their running game, the Chargers' overall talent and efficiency make them the favored choice for a profitable bet.

The Chargers are deserved favorites, but the Giants' huge +238 odds offer exceptional value considering their home field advantage and defensive playmaking potential against the spread, making them the profitable long-shot bet.

The New York Giants, bolstered by home-field advantage and favorable odds, present a strong value bet against a Chargers team that may be overvalued.