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Betting tips from AI for San Francisco 49ers vs Arizona Cardinals, 21 September 2025.
AI Consensus
2.02
Home win
6 of 6 AI models pick San Francisco 49ers to win at 2.02
ChatGPT tip
San Francisco 49ers
Back the 49ers moneyline at -150; their trench edge, scheme, and home strength make this a positive-EV favorite versus a still-rebuilding Cardinals side.
Gemini tip
San Francisco 49ers
Despite the Cardinals' potential for an upset with Kyler Murray, the San Francisco 49ers' superior roster, coaching, and historical dominance in this divisional matchup make them the reliable choice at home.
Claude tip
San Francisco 49ers
San Francisco's superior offensive line protection and dominant defense should overwhelm Arizona's struggling offensive line and inconsistent defense at home.
Grok tip
San Francisco 49ers
The San Francisco 49ers are predicted to win against the Arizona Cardinals due to their superior defense, balanced offense, and strong home record in divisional matchups. Betting on the 49ers at -150 offers reliable value over the underdog Cardinals.
DeepSeek tip
San Francisco 49ers
The 49ers offer strong value at -150 odds due to their elite defense, home dominance over Arizona, and the Cardinals' persistent road vulnerabilities in divisional matchups.
Qwen tip
San Francisco 49ers
The San Francisco 49ers are favored due to their dominant history against Arizona, strong defense, and efficient offense, making them the safer bet despite the Cardinals' potential for an upset.
See how multiple AI models rate San Francisco 49ers vs Arizona Cardinals. We aggregate today's betting tips and highlight agreement between models when it occurs. Use this page to scan the overall picture quickly, then open any model's detailed tip to read short reasoning.