Betting tips from AI for Seattle Seahawks vs San Francisco 49ers, 18 January 2026.

Seattle looks set to control this divisional game: their running backs gashed San Francisco for 171 yards in the Week 18 13-3 rout and Seattle’s rush attack plus a blitz-happy defense create a matchup tilt. Brock Purdy’s two picks in the wild-card highlight San Francisco’s passing fragility, and the Niners’ offense must rebound to avoid another low-scoring loss. Book odds favor Seattle heavily at 1.29 while San Francisco sits at 3.81.

Play it safe and back the home favorites. Lumen Field energy, Seattle’s seven-game win streak, and models tipping the Hawks make Seattle the smart money here; expect a grind-it-out victory and a relatively small payoff but high win probability.

The Seattle Seahawks are poised for a dominant performance at home, and the betting lines reflect this, with Seattle at 1.29. Their formidable running back duo, Kenneth Walker III and Zach Charbonnet, shredded the 49ers for 171 yards in their last encounter, indicating they can control the clock and dictate the pace. This strategy could lead to another low-scoring victory, especially given Sam Darnold's turnover issues if he plays.

Brock Purdy's recent two interceptions against Philly exposed the 49ers' shaky passing game, a concern intensified by Seattle's blitz-happy defense. Pundits at Winners and Whiners are confident Seattle will cover the 7.5-point spread, citing their seven-game win streak and complete domination in both regular-season clashes, including a mere 16 combined points in their last meeting. Lumen Field, where the top-seeded Seahawks boast a 6-2 home record, provides a significant advantage. While CBS Sports notes the 49ers have won seven of the last nine head-to-heads overall, the current form and home-field strength point decisively towards a Seahawks victory.

The Seahawks enter this divisional clash as heavy 1.29 favorites after completely dismantling San Francisco in Week 18. Seattle's ground game was unstoppable, with Walker and Charbonnet combining for 171 rushing yards in that 13-3 victory. This physical dominance should continue against a 49ers defense that hasn't found answers.

Brock Purdy's turnover issues were on full display in the wild-card round, throwing two interceptions against Philadelphia. Now facing Seattle's top-ranked defense in the deafening Lumen Field, where the Seahawks boast a 6-2 home record, Purdy's struggles are likely to continue.

The betting value strongly favors Seattle despite the heavy price. The Seahawks' seven-game winning streak, combined with their complete dominance in both regular-season matchups against San Francisco, makes them the clear choice. While the 49ers' 3.81 odds might tempt some bettors seeking value, the on-field reality suggests Seattle will control this game through their punishing ground attack and opportunistic defense.

The Seattle Seahawks are primed to defend their home turf in this divisional-round showdown against the San Francisco 49ers, leveraging their blistering seven-game win streak and total command in recent head-to-heads. In Week 18, Seattle's running backs Kenneth Walker III and Zach Charbonnet torched San Francisco for 171 rushing yards in a gritty 13-3 victory, proving the Hawks can control the clock and stifle the Niners' attack without relying on shaky quarterback play. Lumen Field's roar will amplify Seattle's blitz-happy defense, ranked tops in the league, putting pressure on Brock Purdy, who coughed up two picks in the wild-card win over Philly and struggled mightily in that offensive no-show against Seattle last time out.

San Francisco's banged-up unit faces a tall order on the road, where the top-seeded Seahawks boast a 6-2 home record and history of thriving in these spots. Despite the 49ers' edge in nine of the last 11 meetings, recent dominance tilts heavily toward Seattle—pundits at Winners and Whiners are all-in on the Hawks covering the 7.5-point spread, and College Football News sees a tight 24-20 edge for Seattle in what could be a low-scoring grind. With the 49ers' passing game exposed and Seattle pounding the rock, this feels like another Hawks masterclass. The odds reflect it at 1.29 for Seattle, but the value lies in their momentum for a profitable home win.

The Seahawks ride a seven-game win streak into this divisional-round battle, with their top-ranked defense poised to capitalize on Brock Purdy's recent interception woes. Seattle's ground game dominated Week 18, as Kenneth Walker III and Zach Charbonnet shredded the 49ers for 171 yards, setting the tone for a clock-controlling approach at deafening Lumen Field. Pundits heavily favor Seattle covering the spread, citing their 6-2 home mark and past regular-season dominance. While San Francisco at 3.81 offers tempting upset value, the Seahawks at 1.29 should grind out a low-scoring victory with their blitz-happy defense stifling Purdy's shaky passing attack.

Seattle Seahawks enter this divisional-round clash as heavy favorites with odds of 1.29, and for good reason. Their dominance over San Francisco was on full display in Week 18 when Kenneth Walker III and Zach Charbonnet combined for 171 rushing yards, grinding out a 13-3 victory that showcased their ability to control the clock and neutralize the 49ers' defense. With Sam Darnold’s turnover issues, Seattle's commitment to the run game could again prove decisive against a San Francisco team struggling to find consistency.
San Francisco's Brock Purdy has shown flashes of brilliance but also vulnerability, throwing two interceptions in their wild-card win over Philadelphia. Against Seattle's blitz-heavy defense, which ranks among the league's best, Purdy will need to be nearly flawless—a tall order on the road at deafening Lumen Field. The Seahawks' 6-2 home record further underscores their advantage in hostile environments, while their seven-game win streak highlights their current form.
While pundits suggest a close contest, Seattle's recent performances and historical edge in head-to-head matchups tilt the scales significantly. Betting on the Seahawks at 1.29 may not offer massive returns, but their reliability makes them a safer pick than San Francisco at 3.81.